1995: RCTs of dose and duration Lin, et al., J Hepatology; 23: 487-96.
- Large, multicenter, RCT.
- Methodology clearly outlined; good randomization.
- Large number of drop-outs in 2 year treatment group led to analysis of variable lengths of treatment. Data difficult to interpret. Should not have affected comparisons between first two groups, however.
- Supported by Schering-Plough.