1998: The future begins… Ribavirin and interferon
combination group IFN alone
virological SR 36% 18% ( p= 0.047)
- NNT with combination therapy vs. IFN alone to achieve one virological SR = 5-6.
- Biochemical SR was increased; p= 0.057, NNT= 5
- End of treatment responses were not different.
- Pts with high RNA levels ( ɯ x 10 6 Eq/ml) were more likely to have SR with combination therapy than with IFN alone; 41% vs. 4%, p= 0.009, NNT= 3.