Table of Contents
Drug Allergy
Adverse Reactions to Drugs
Adverse Drug Reactions
Types of Allergic Reactions
Types of Allergic Reactions
Symptoms of allergic drug reactions
Anaphylaxis versus Anaphylactoid Reactions
Multivalency
Multivalency
Haptenization
Conversion into reactive intermediates
Factors that Increase the Risk of Allergic Reactions
Evaluation of Drug Allergy
Evaluation of Drug Allergy
RAST Testing
Disadvantages of RAST testing
Evaluation of drug allergy
Drug Desensitization
Drug Desensitization
Desensitization
Desensitization
Desensitization
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Penicillins
Major and minor determinants
Minor Determinants
Signs and symptoms
Signs and Symptoms
Skin testing
Sogn et al
Sogn et al
Skin testing
Skin Testing
Cephalosporins
Cephalosporins
Skin testing with Cephalosporins
Summary of Studies of Cephalosporin to Patients with Histories of Penicillin Allergy and Penicillin Skin Test Evaluations
PPT Slide
Sulfa Drugs
Sulfa Drugs
Sulfa Drugs and HIV
Hennessy et al
Hennessy et al
Signs and Symptoms
History of Rash and Rechallenge
Sulfonamide Hypersensitivity Reaction
Sulfonamide Hypersensitivity Reaction
Stevens Johnson syndrome and TEN with sulfa drugs
Mechanism
Sulfa Drug Metabolism
Sulfa drug Metabolism
Slow acetylation
Slow Acetylation in AIDS patients
Slow acetylation in AIDS patients
Slow acetylation in AIDS patients
Skin Testing
Desensitization
Desensitization
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NSAIDS
NSAID Intolerance (NI)
Mechanisms
Mechanisms
Mechanisms
Mechanisms
COX Inhibition
COX Inhibition
Chronic inflammation of the airways
Delayed reactions to NSAIDS
Signs and Symptoms
Testing
Oral ASA Challenge
Oral ASA Challenge
Prevention and Treatment
Prevention and Treatment
Prevention and Treatment
COX-2 Inhibitors
Desensitization
Desensitization
Stevenson et al
Stevenson et al
Stevenson et al
Conclusion
Conclusion
Conclusion
Conclusion
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