History of Rash and Rechallenge
A history of rash is not necessarily a contraindication to retreatment as less than 20% may have a recurrence on rechallenge.
Shafer et al
- 34 homosexual men given IV cotrimazole for PCP with development of hypersensitivity reactions in 21 of these patients (erythematous macular or maculopapular rashes, fever). All 31 survivors were started on oral cotrimazole for PCP prophylaxis but only 4 developed reactions which necessitated discontinuation of the drug (desquamative rash, fever, etc..)