Sulfa drug Metabolism

Sulfamethoxazole is predominantly cleared by acetylation and excreted by active tubular excretion. The alternative pathway yields a reactive metabolite, sulfamethoxazole hydroxylamine, which can generate an immune response.
- Generally, slow acetylators develop more adverse reactions, whereas rapid acetylators are more prone to show an inadequate response to a standard dose.

Sulfamethoxazole is predominantly cleared by acetylation and excreted by active tubular excretion. The alternative pathway yields a reactive metabolite, sulfamethoxazole hydroxylamine, which can generate an immune response.