Slow acetylation in AIDS patients
The cause of the increased prevalence of slow acetylation in acutely ill AIDS patients is not known.
Due to slow acetylation, more of the drug is shunted to alternative oxidative pathways.
- These pathways form toxic metabolites which are normally detoxified by scavengers, such as glutathione. A few studies have reported decreased levels of GSH in HIV patients but this has not been confirmed in other studies.