Oral ASA Challenge
Patients with a history of severe or very rapid ASA or NSAID-induced reactions may be started with a dose lower than 30 mg.
As soon as signs and symptoms of reactions occur (20% decrease in FEV1, rhinorrhea, ocular injection, periorbital edema, stridor, and rarely flushing, urticaria, cramps, or explosive diarrhea), the ASA challenge is stopped.
Oral challenges to detect anaphylaxis should not be done; history of anaphylaxis should be relied upon instead.