Desensitization
NSAID allergic patients can also be desensitized.
Small incremental doses of ASA are taken over 2 to 3 days until 400 to 650 mg of ASA is tolerated. ASA should then be given daily, with doses ranging from 80 to 325 mg to maintain desensitization.
After each dose of ASA, there is a refractory period of 2 to 5 days, during which ASA and other COX inhibitors can be given without any risk of an allergic reaction.