Conclusion
NSAID intolerance prevalence in asthma and nasal polyposis or rhinosinusitis is 30-40%. Aspirin-induced asthma affects 10% of adults with asthma. The only way to test for NSAID intolerance in the US is with an oral provocation test. High dose acetaminophen has been shown to have a cross-reaction prevalence of 34%. After ASA desensitization, cross desensitization to other NSAIDS than inhibit cyclooxygenase also occurs. The patient most likely to benefit from desensitization is one with AIA who has just had sinus/polyp surgery.