Types of Allergic Reactions
Type I - Immediate Reactions - IgE-mediated systemic rxns of mast cells and basophils
- Usually occur within 1 hour of admin. - Consist of any combination of diffuse erythema, pruritus, urticaria, angioedema, bronchospasm, laryngeal edema, hyperperistalsis, hypotension and cardiac arrhythmias.
- 0.004%-0.015% of tx courses - Most often in adults 20-49 years. - More common if hx of atopy or parenteral admin - Fatal outcomes in 1 per 50,000-100,000 admin.
- Skin testing does have a role in evaluation of these pts.