What about cephalosporins?
Three approaches to using cephalosporins in pts. with PCN allergy. 1. avoid all beta-lactams - the most popular = increased cost and resistance 2. use common sense - not as common as you might think. Take good hx and give cephalosporin if rxn to PCN was not life threatening 3. test pts. with skin testing - if strong indication for cephalosporin and pt. has hx of IgE rxn to PCN