Citation: _____________________________________________________________________
| GUIDE | COMMENTS |
I. Are the Results Valid? |
|
| 1. Was the assignment of patients to treatments randomized? | |
| 2. Were all
patients who entered the trial properly accounted for and attributed at its conclusion? a. Was follow-up complete? b. Were patients analyzed in the groups to which they were randomized? |
|
| 3. Were patients, clinicians, and study personnel "blind" to treatment? | |
| 4. Were the groups similar at the start of the trial? |
|
| 5. Aside from the experimental intervention, were the groups treated equally? | |
| II. What Are the Results? | |
| 1. How large was the treatment effect? | |
| 2. How precise is the estimate of the treatment effect? | |
| III. Will the Results Help Me in My Patient Care? | |
| 1. Can the results be applied to my patients? | |
| 2. Were all clinically important outcomes considered? | |
| 3. Are the benefits worth the harms and costs? | |
References: JAMA 1993; 270: 2598-2601 JAMA 1994; 271: 59-63