Tinsley R. Harrison Translational Research Program Scholars

2009-2010                2008-2009                2007-2008                2006-2007

Academic Year 2009-2010

Sharmin Basher, MD, MS

Mentor: David Sane, MD, Division of Cardiology

Project Title: Omega-3 Fatty Acids, Vitamin D, and DHA as Markers of Atrial Arrhythmia

Farah Dawood, MD

Mentor: Tony Simmons, MD and David Sane, MD, Division of Cardiology

Project Title: Connexin40 Expression and Immunohistochemical analysis of Atrial Myocytes:

Brandon Drafts, MD, MBS

Mentor: Greg Hundley, MD, Division of Cardiology

Project Title: An Evaluation of the Prognostic Utility of Exercise Treadmill Cardiac MRI Testing

Michael Goebel, MD

Mentor: Richard Weinberg, MD, Division of Gastroenterology

Project Title: Non-Invasive In-Vivo Measurement of Gastric Acid Secretion Using a Radiotelemetry Capsule

Xanthia Samaropoulos, MD, MPH

Mentor: David Goff, MD, Division of Public Health Sciences, Section on Epidemiology and Prevention

Project Title: Correlation of Vitamin D deficiency, Type 2 Diabetes Mellitus, and Increased Fracture Risk 

Academic Year 2008-2009

Michael John Babcock, MD

Mentor: David Goff, MD, Division of Public Health Sciences, Section on Epidemiology and Prevention

Project Title: Pericardial adipose tissue as it correlates with atrial conduction abnormalities in the MESA cohort

Presented at: Wake Forest Internal Medicine Research Day (2009)

Publications generated: Submitted for publication

Paul Wesley Benson, MD

Mentor: Richard Weinberg, MD, Division of Gastroenterology

Project Title: Bitter Taster Status Predicts Susceptibility to Vection-Induced Nausea

Presented at: Wake Forest Internal Medicine Research Day (2009)

Publications generated: Pending

Kevin R. Hayes, MD

Mentor: Robert Applegate, MD, Division of Cardiology

Project Title: Clinical Outcomes of Bare Metal Stents Versus Drug-Eluting Stents, Target Vessel Revascularization: Evidence For A High Risk Bare Metal Stent Cohort

Presented at:  American College of Cardiology. Orlando, Florida 2009

Publications generated: Pending

Steven J. Heatherly, MD

Mentor: Tony Simmons, MD, Division of Cardiology

Project Title: Psychological Effects of Recalled Implantable Cardioverter-Defibrillators

Publications generated: Pending

GiGi MacDonald, MD

Mentor: Mary Ann Knovich, MD and John Owen, MD, Division of Hematology and Oncology

Project Title: ADAMTS13 Activity Assay

Publications generated: Pending

Candace B. Anz, MD

Mentor: Raymond Penn, PhD, Center for Human Genomics

Project Title: EP receptor subtype function and crosstalk in human airway smooth muscle (HASM)

Presented at: American Thoracic Society International Meeting (2008), Wake Forest Internal Medicine Research Day (2008)

Publications generated: Kong KC, Gandhi U, Martin TJ, Anz CB, Yan H, Misior AM, Pascual RM, Deshpande DA, Penn RB.  Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization. Biochemistry. 2008 Sep 2;47(35):9279-88.

T. J. Martin, MD

Mentor: Raymond Penn, PhD, Center for Human Genomics

Project Title: EP receptor subtype function and crosstalk in human airway smooth muscle (HASM)

Presented at: American Thoracic Society International Meeting (2008), Wake Forest Internal Medicine Research Day (2008)

Publications generated: Kong KC, Gandhi U, Martin TJ, Anz CB, Yan H, Misior AM, Pascual RM, Deshpande DA, Penn RB.  Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization. Biochemistry. 2008 Sep 2;47(35):9279-88.

John A. Piede, MD

Mentor: Bayard Powell, MD, Division of Hematology and Oncology

Project Title: The Evaluation of Bronchoscopy in Acute Leukemia: A Retrospective Chart Review

Presented at: North Carolina American College of Physicians Regional Meeting (First place clinical research award 2009) and American College of Physicians National Meeting (2009), American Society of Hematology (2008), and Wake Forest Internal Medicine Research Day (2008)

Publications generated: Piede J, Ellis L, High K, Case D,  Powell B."The Evaluation of Bronchoscopy in Acute Leukemia: A Retrospective Chart Review." Blood (ASH Annual Meeting Abstracts). November 2008; Volume 112, Issue 11: 3990. Manuscript pending.

Eric L. Wallace, DO

Mentor: W. Greg Hundley, MD, Division of Cardiology

Project Title: Prognostic Utility of Cardiac MRI in Women

Presented at: American College of Cardiology Scientific Conference, Chicago, Illinois 2008. Wake Forest Internal Medicine Research Day (First place clinical research 2008)

Publications generated: Wallace EL, Morgan TM, Walsh TF, Dall'Armellina E, Ntim W, Hamilton CA, and Hundley WG. Dobutamine Cardiovascular Magnetic Resonance Results Predict Cardiac Prognosis in Women with Known or Suspected Ischemic Heart Disease. Journal of the American College of Cardiology: Cardiovascular Imaging. J. Am. Coll. Cardiol. Img., March 1, 2009;2(3):299-307.

Charoenpanichkit C, Morgan TM, Hamilton CA, Wallace EL, Robinson KC, Ntim W, Hundley WG. Prognostic Importance of Left Ventricular Mass in Patients Undergoing Dobutamine Stress Testing. Submitted for publication.

Rachel W. Holt, MD

Mentor: Richard Loeser, MD, Division of Rheumatology, Division of Molecular Medicine

Project Title: The Effect of Vitamin K on Chondrocyte Gene Expression

Matthew C. Miles, MD

Mentor: Raymond Penn, PhD, Center for Human Genomics

Project Title: EP-receptor Agonism and Functional Consequences in Human Airway Smooth Muscle

Presented at: American Thoracic Society International Conference, San Francisco, May 2007, Wake Forest Internal Medicine Research Day (2007).

Matthew Nelson, MD

Mentor: Kurt Daniel, DO and David Herrington, MD, Division of Cardiology

Project Title: Coronary Artery Calcium and ECG Interval Duration

Presented at: American Heart Association National Meeting, Orlando, FL; Wake Forest Internal Medicine Research Day (2007); North Carolina American College of Physicians (2008)

Publications generated: Nelson MR, Daniel KR, Carr JJ, Freedman BI, Prineas RJ, Bowden DW, Herrington DM. Associations between electrocardiographic interval durations and coronary artery calcium scores: the Diabetes Heart Study. Pacing Clin Electrophysiol. 2008 Mar;31(3):314-21

Lehtinen AB, Daniel KR, Shah SA, Nelson MR, Ziegler JT, Freedman BI, Carr JJ, Herrington DM, Langefeld CD, Bowden DW. Relationship between genetic variants in myocardial sodium and potassium channel genes and QT interval duration in diabetics: the Diabetes Heart Study. Ann Noninvasive Electrocardiol. 2009 Jan;14(1):72-9.